Mastery 10
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Overload
Overcharge always critically hits while the enemy has no debuffs.
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Mind Barrier
Mind Crush's shield now triggers on every cast.
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Life Drinker
Leech Fiend now also instantly heals you for 5% of your max life, modified by your healing done.
Mastery 20
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Lasting Curses
Your curses last 1 turn longer.
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Hex Shock
Applying one of your curses increases all the enemy's cooldowns by 1. This can only happen once every 3 turns.
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Grim Advantage
While the enemy has no debuffs, you have 20% increased critical strike chance, your critical strikes deal 20% more damage, and you take 10% less damage.
Mastery 30
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Soul Plunder
Soul Haunt now has a 50% chance per enemy debuff (up from 30%) to shield you and remove 1 buff, and its absorb is also increased to 75% of the damage (up from 50%).
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Blood Harvest
Harvest Life now heals you for 50% of the damage per enemy debuff, up from 30%.
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Doomfall
Meteor Strike's damage is doubled while the enemy has no debuffs, but it can no longer critically strike, and it now halves the enemy's energy instead of destroying all of it.
Mastery 40
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Spectral Mantle
You permanently take 30% less critical strike damage.
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Void Ward
You take 15% less damage while the enemy has no debuffs.
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Demonhide
You permanently take 5% less damage, plus an extra 5% for each debuff on the enemy.
Mastery 50
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Festering Wound
Affliction becomes unremovable and now grants 1 energy on every tick, instead of only on critical ones. Overload, Grim Advantage, Doomfall, and Void Ward now work even while Affliction is on the enemy.
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Plague Bearer
Sickness becomes unremovable and now steals 5% damage and 5% healing per turn, up from 2%. Overload, Grim Advantage, Doomfall, and Void Ward now work even while Sickness is on the enemy.
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Bloodletting
Transfusion becomes unremovable and now heals you for 150% of the damage it deals, up from 75%. Overload, Grim Advantage, Doomfall, and Void Ward now work even while Transfusion is on the enemy.
Mastery 60
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Stolen Swiftness
Tentacle Grip now steals the enemy's Speed instead of just lowering it.
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Plague Mark
Prolong Agony now applies Affliction, Sickness, and Transfusion for 2 turns, instead of extending your debuffs.
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Karmic Mirror
The debuff redirected by Redirect Pain now lasts 2 turns longer on the enemy.
Mastery 70
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Insidious Afflictions
When you cast Nightmare, Blood Curse, or Soul Burn, you also apply a random one of Affliction, Sickness, or Transfusion to the enemy.
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Cursed Remedy
When the enemy removes one of your debuffs, you gain 1 energy.
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Vampiric Thirst
Overcharge, Mind Crush, Soul Haunt, and Meteor Strike now heal you for 30% of the damage dealt.
Mastery 80
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Unending Nightmare
Nightmare now reduces the enemy's healing by 80%, up from 40%. Overload, Grim Advantage, Doomfall, and Void Ward now work even while Nightmare is on the enemy.
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Sanguine Curse
Blood Curse now heals you for 100% of its damage per turn, up from 60%. Overload, Grim Advantage, Doomfall, and Void Ward now work even while Blood Curse is on the enemy.
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Soul Siphon
Soul Burn now steals the enemy's energy to you each turn instead of destroying it. Overload, Grim Advantage, Doomfall, and Void Ward now work even while Soul Burn is on the enemy.
Mastery 90
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Crippling Curse
While the enemy has a debuff and your life percentage is lower than the enemy's, critical damage from enemies is reduced by 60%.
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Deathcap Infusion
Your direct hits with Overcharge, Mind Crush, and Leech Fiend apply a Deathcap buff to you for 2 turns. Each turn, Deathcap randomly increases your damage done by 5%, your critical strike chance by 5%, your healing done by 5%, or your critical modifier by 10%.
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Eternal Pact
Once per combat, the first time you would die, you return to life with 20% of your max life.
Mastery 100
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Cursed Aegis
Skull Shield's absorb is doubled.
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Dark Signet
You take 15% less damage while above 50% of your life.
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Soul Ward
You start each combat with an absorb equal to 20% of your max life.